H1 tau haplotype-related genomic variation at 17q21.3 as an Asian heritage of the European Gypsy population.

Álmos, Péter Zoltán and Horváth, Szatmár and Czibula, Ágnes and Raskó, István and Sipos, Botond and Bihari, Péter and Béres, Judit and Juhász, Anna and Janka, Zoltán and Kálmán, János (2008) H1 tau haplotype-related genomic variation at 17q21.3 as an Asian heritage of the European Gypsy population. HEREDITY, 101 (5). pp. 416-419. ISSN 0018-067X

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Abstract

In this study, we examine the frequency of a 900 kb inversion at 17q21.3 in the Gypsy and Caucasian populations of Hungary, which may reflect the Asian origin of Gypsy populations. Of the two haplotypes (H1 and H2), H2 is thought to be exclusively of Caucasian origin, and its occurrence in other racial groups is likely to reflect admixture. In our sample, the H1 haplotype was significantly more frequent in the Gypsy population (89.8 vs 75.5%, P<0.001) and was in Hardy-Weinberg disequilibrium (P=0.017). The 17q21.3 region includes the gene of microtubule-associated protein tau, and this result might imply higher sensitivity to H1 haplotype-related multifactorial tauopathies among Gypsies.

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