Pintér, Dávid and Janszky, József Vladimír and Kovács, Norbert (2020) Minimal Clinically Important Differences for Burke-Fahn-Marsden Dystonia Rating Scale and 36-Item Short-Form Health Survey. MOVEMENT DISORDERS, 35 (7). pp. 1218-1223. ISSN 0885-3185
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Abstract
Although an increasing number of trials are reported on the treatment of generalized or segmental isolated dystonia, the minimal clinically important difference thresholds for the most frequently reported outcome measures are still undetermined.To estimate the minimal clinically important difference for the Burke-Fahn-Marsden Dystonia Rating Scale and the 36-Item Short-Form Health Survey in generalized or segmental dystonia.A total of 898 paired examinations of 198 consecutive patients, aged >18 years, with idiopathic and inherited (torsin family 1 member A positive) segmental and generalized isolated dystonia were analyzed. To calculate the minimal clinically important difference thresholds, both anchor- and distribution-based methods were used simultaneously.Any improvement >16.6% or worsening larger than 21.5% on the Burke-Fahn-Marsden Dystonia Rating Scale indicates a minimal, yet clinically relevant, change. Threshold values for the Burke-Fahn-Marsden Dystonia Disability Scale were 0.5 points for both decline and improvement. Cut-off scores for the Physical Component Summary, the Mental Component Summary, and the Global (Total or Overall) Score of the 36-Item Short-Form Health Survey were 5.5 and 5.5, 6.5 and 7.5, and 7.5 and 8.5 points for clinically meaningful improvement and deterioration, respectively.The minimal clinically important difference represents the smallest change in an outcome measure that is meaningful to patients. Our estimates for the Burke-Fahn-Marsden Dystonia Rating Scale and the 36-Item Short-Form Health Survey may allow more reliable judgment of the clinical relevance of different treatments for segmental and generalized isolated dystonia. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
| Item Type: | Article |
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| Additional Information: | Journal Article; Research Support, Non-U.S. Gov't Funding Agency and Grant Number: Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]; NKFIH [EFOP3.6.2-16-2017-00008, EFOP3.6.1.-16-2016-00004, SNN125143]; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765/3/2018/FEKUSTRAT]; European Reference Network for Rare Neurological Diseases [739510] Funding text: This study was supported by the Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002), NKFIH EFOP3.6.2-16-2017-00008, NKFIH SNN125143, and NKFIH EFOP3.6.1.-16-2016-00004 government-based funds. Our research was partly financed by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the 5th thematic program of the University of Pecs, Hungary (20765/3/2018/FEKUSTRAT). All the authors of this publication are members of the European Reference Network for Rare Neurological Diseases (Project ID No.: 739510). Department of Neurology, Medical School, University of Pécs, Pécs, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary Cited By :1 Export Date: 9 October 2020 CODEN: MOVDE Correspondence Address: Pintér, D.; Department of Neurology, Medical School, University of PécsHungary; email: david_pinter@outlook.com |
| Uncontrolled Keywords: | Dystonia; Deep brain stimulation; minimal clinically important difference; 36-Item Short-Form Health Survey; Burke-Fahn-Marsden Dystonia Rating Scale; |
| Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 04 Jan 2021 13:06 |
| Last Modified: | 04 Jan 2021 13:06 |
| URI: | http://real.mtak.hu/id/eprint/119049 |
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