Gelatin content governs hydration induced structural changes in silica-gelatin hybrid aerogels – Implications in drug delivery

Kéri, Mónika and Forgács, Attila and Papp, Vanda and Bányai, István and Veres, Péter and Len, Adél and Dudás, Zoltán Imre and Fábián, István and Kalmár, József (2020) Gelatin content governs hydration induced structural changes in silica-gelatin hybrid aerogels – Implications in drug delivery. ACTA BIOMATERIALIA, 105. pp. 131-145. ISSN 1742-7061

Preview

Text 1-s2.0-S1742706120300179-main.pdf Download (2MB) | Preview

Abstract

Silica-gelatin hybrid aerogels of varying gelatin content (from 4 wt.% to 24 wt.%) can be conveniently impregnated with hydrophobic active agents (e.g. ibuprofen, ketoprofen) in supercritical CO2 and used as drug delivery systems. Contrast variation neutron scattering (SANS) experiments show the molecular level hybridization of the silica and the gelatin components of the aerogel carriers. The active agents are amorphous, and homogeneously dispersed in these porous, hybrid matrices. Importantly, both fast and retarded drug release can be achieved with silica-gelatin hybrid aerogels, and the kinetics of drug release is governed by the gelatin content of the carrier. In this paper, for the first time, a molecular level explanation is given for the strong correlation between the composition and the functionality of a family of aerogel based drug delivery systems. Characterization of the wet aerogels by SANS and by NMR diffusiometry, cryoporometry and relaxometry revealed that the different hydration mechanisms of the aerogels are responsible for the broad spectrum of release kinetics. Low-gelatin (4–11 wt.%) aerogels retain their open-porous structure in water, thus rapid matrix erosion dictates fast drug release from these carriers. In contrast to this, wet aerogels of high gelatin content (18–24 wt.%) show well pronounced hydrogel-like characteristics, and a wide gradual transition zone forms in the solid-liquid interface. The extensive swelling of the high-gelatin hybrid backbone results in the collapse of the open porous structure, that limits mass transport towards the release medium, resulting in slower, diffusion controlled drug release.

Actions (login required)

Edit Item