Age dependence of serum beta-N-acetylhexosaminidase (NAG) activity

Vargáné Oláh, Anna and Price, R. G. and Csáthy, László and Orszagh, É. and Oláh, Éva and Varga, József (2004) Age dependence of serum beta-N-acetylhexosaminidase (NAG) activity. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 42 (3). pp. 305-306. ISSN 1434-6621


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Serum Nacetyl-beta-Dglucosaminidase (NAG; EC is a hexosaminidase and may be a predictor of vascular injury, e.g., in infant respiratory distress syndrome, pneumonia, bronchopulmonary dysplasia and necrotizing enterocolitis. To estimate the new diagnostic prospects we have modified our urinary NAG assay. In this sensitive colorimetric microassay, VRAGlcNAc was used as a substrate. In the present study the age dependence of serum NAG activity was investigated in newborn babies, infants (124 months), children (218 years) and adults (1980 years). Serum NAG activity was found to be agedependent; it is higher in early childhood (1159 U/l) but decreases to a constant value at the age of 12 years. After the age of 2 years it is similar to adults NAG (1030 U/l). In pediatrics agematched reference ranges must be taken into consideration.

Item Type: Article
Uncontrolled Keywords: beta-N-Acetylhexosaminidases/*blood; Thiazoles/chemistry/metabolism; Statistical Distributions; Spectrum Analysis; Reference Values; Middle Aged; Male; Infant, Newborn; Infant; Humans; Female; Clinical Enzyme Tests/methods; Child, Preschool; Child; CATALYSIS; Aged, 80 and over; Aged; Age Factors; Adult; Adolescent; Acetylglucosamine/*analogs & derivatives/chemistry/metabolism
Subjects: R Medicine / orvostudomány > RJ Pediatrics / gyermekgyógyászat
Depositing User: MTMT SWORD
Date Deposited: 19 May 2014 13:31
Last Modified: 03 Jun 2014 07:38

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