Plasma carnitine ester profile in Crohn's disease and ulcerative colitis patients with different IGR2230a_1 genotypes

Talián, Gábor and Lakner, Ł. and Bene, J. and Komlósi, K. and Horváth, K. and Gasztonyi, Beáta and Miheller, Pál and Figler, Mária and Mózsik, Gyula and Tulassay, Zsolt and Melegh, Béla (2009) Plasma carnitine ester profile in Crohn's disease and ulcerative colitis patients with different IGR2230a_1 genotypes. International Journal of Immunogenetics, 36 (6). pp. 329-335. ISSN ISSN 1744-3121, ESSN 1744-313X

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An association has been repeatedly demonstrated between inflammatory bowel disease (IBD) and the IBD5 locus in the 5q31 chromosomal region. The aim of the present study was to examine the prevalence of the IGR2230a_1 intronic nucleotide polymorphism of the slc22a5 gene (coding for the OCTN2 carnitine transporter protein) lying within this region, and its possible relationship with the carnitine metabolism in Hungarian IBD patients and controls. We genotyped by restriction fragment length polymorphism 200 Crohn's disease (CD) and 246 ulcerative colitis (UC) patients, as well as 187 healthy controls. From plasma samples we determined detailed carnitine ester profiles of 76 CD, 43 UC patients and 45 control persons using electrospray ionization triple quadruple tandem mass spectrometry. The distribution of the genotypes was not significantly different in the CD or the UC group compared with the controls. We found no significant alterations of the carnitine profile in the carrier/non-carrier or the homozygote/non-homozygote comparisons in both the CD and the UC groups, stratified by IGR2230a_1 genotype. Our data suggest that this polymorphism alone is not associated with CD and UC in the Hungarian population, and has no effect on the carnitine metabolism.

Item Type: Article
Uncontrolled Keywords: Zala Megyei Kórház tudományos közleményei
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
Depositing User: xGabriella xBeke
Date Deposited: 27 May 2014 13:15
Last Modified: 05 Aug 2014 08:36

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