Template-based structure modeling of protein-protein interactions

Szilágyi, András and Zhang, Yang (2014) Template-based structure modeling of protein-protein interactions. CURRENT OPINION IN STRUCTURAL BIOLOGY, 24 (1). pp. 10-23. ISSN 0959-440X

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Abstract

The structure of protein-protein complexes can be constructed by using the known structure of other protein complexes as a template. The complex structure templates are generally detected either by homology-based sequence alignments or, given the structure of monomer components, by structure-based comparisons. Critical improvements have been made in recent years by utilizing interface recognition and by recombining monomer and complex template libraries. Encouraging progress has also been witnessed in genome-wide applications of template-based modeling, with modeling accuracy comparable to high-throughput experimental data. Nevertheless, bottlenecks exist due to the incompleteness of the protein-protein complex structure library and the lack of methods for distant homologous template identification and full-length complex structure refinement. © 2013.

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