Template-based structure modeling of protein-protein interactions

Szilágyi, András and Zhang, Yang (2014) Template-based structure modeling of protein-protein interactions. CURRENT OPINION IN STRUCTURAL BIOLOGY, 24 (1). pp. 10-23. ISSN 0959-440X


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The structure of protein-protein complexes can be constructed by using the known structure of other protein complexes as a template. The complex structure templates are generally detected either by homology-based sequence alignments or, given the structure of monomer components, by structure-based comparisons. Critical improvements have been made in recent years by utilizing interface recognition and by recombining monomer and complex template libraries. Encouraging progress has also been witnessed in genome-wide applications of template-based modeling, with modeling accuracy comparable to high-throughput experimental data. Nevertheless, bottlenecks exist due to the incompleteness of the protein-protein complex structure library and the lack of methods for distant homologous template identification and full-length complex structure refinement. © 2013.

Item Type: Article
Uncontrolled Keywords: template based modeling; structure analysis; review; protein tertiary structure; protein structure; PROTEIN SECONDARY STRUCTURE; protein quaternary structure; protein protein interaction; priority journal; PREDICTION; Molecular docking; BINDING SITE; binding affinity; analytic method; ALGORITHM; accuracy
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
Depositing User: MTMT SWORD
Date Deposited: 29 May 2014 08:57
Last Modified: 29 May 2014 08:57

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