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Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model

Hegyi, Péter J. and Soós, Alexandra and Tóth, Emese and Ébert, Attila and Venglovecz, Viktória and Márta, Katalin and Mátrai, Péter and Mikó, Alexandra and Bajor, Judit and Sarlós, Patrícia and Vincze, Áron and Halász, Adrienn and Izbéki, Ferenc and Szepes, Zoltán and Czakó, László and Kovács, György and Papp, Mária and Dubravcsik, Zsolt and Varga, Márta and Hamvas, József and C. Németh, Balázs and Erőss, Bálint and Pécsi, Dániel and Szentesi, Andrea and Párniczky, Andrea and Tiszlavicz, László and Hegyi, Péter (2021) Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model. SCIENTIFIC REPORTS, 11. pp. 1-14. ISSN 2045-2322

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Abstract

Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában > R850-854 Experimental medicine / kisérleti orvostudomány
R Medicine / orvostudomány > RC Internal medicine / belgyógyászat
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 21 Sep 2021 16:50
Last Modified: 21 Sep 2021 16:50
URI: http://real.mtak.hu/id/eprint/130048

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