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Pregnancy and deep brain stimulation therapy for epilepsy

Bóné, Beáta and Kovács, Norbert and Balás, István and Horváth, Réka and Dóczi, Tamás Péter and Janszky, József Vladimír (2021) Pregnancy and deep brain stimulation therapy for epilepsy. EPILEPTIC DISORDERS, 23 (4). pp. 633-638. ISSN 1294-9361

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Abstract

Neuromodulation therapy -vagus nerve stimulation (VNS) and deep brain stimulation (DBS)- is one of the therapeutic options for drug-resistant epilepsy. With the increasing number of DBS implantations in women with epilepsy, it has become a burning issue whether DBS is safe in pregnancy. We report here two women with epilepsy who gave birth to healthy children with DBS therapy. We describe two cases, a 30-year-old woman and a 37-year-old woman. Both were implanted with DBS due to drug-resistant epilepsy. Both of our patients showed a significant improvement after DBS implantation and thereafter gave birth to a healthy child with DBS treatment. The severity and frequency of epileptic seizures did not change during pregnancy and after childbirth. Although a Caesarean section was performed in one case, pregnancies and births were essentially problem-free. At present, the two- and four-year-old children are healthy. Considering these cases, previously described VNS cases, and DBS cases with non-epileptic indications; we suggest that pregnancy and childbirth are safe in epilepsy patients with DBS, moreover, DBS treatment has probably no effect on foetal abnormalities or breastfeeding.

Item Type: Article
Additional Information: Funding Agency and Grant Number: Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]; NKFIHNational Research, Development & Innovation Office (NRDIO) - Hungary [EFOP-3.6.2-16-2017-00008]; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765/3/2018/FEKUSTRAT] Funding text: This article was supported by the Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002), NKFIH EFOP-3.6.2-16-2017-00008 government-based funds. Our research was partly financed by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the 5th thematic program of the University of Pecs, Hungary (20765/3/2018/FEKUSTRAT). Department of Neurology, Medical School, University of Pécs, Pécs, Hungary MTA-PTE Clinical Neuroscience MRI Research Group, Hungary, Pécs, Hungary Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary Diagnostic Center of Pécs, University of Pécs, Pécs, Hungary Export Date: 30 August 2021 CODEN: EPDIF Correspondence Address: Janszky, J.; Department of Neurology, Hungary; email: janszky.jozsef@pte.hu Department of Neurology, Medical School, University of Pécs, Pécs, Hungary MTA-PTE Clinical Neuroscience MRI Research Group, Hungary, Pécs, Hungary Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary Diagnostic Center of Pécs, University of Pécs, Pécs, Hungary Export Date: 14 September 2021 CODEN: EPDIF Correspondence Address: Janszky, J.; Department of Neurology, Hungary; email: janszky.jozsef@pte.hu
Uncontrolled Keywords: RISK; EPILEPSY; pregnancy; maternal mortality; Deep brain stimulation; Women of childbearing age; foetal malformations;
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 29 Dec 2021 20:51
Last Modified: 29 Dec 2021 20:51
URI: http://real.mtak.hu/id/eprint/135037

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