Balasubramanian, Priya and Kiss, Tamás and Tarantini, Stefano and Nyúl-Tóth, Ádám and Ahire, Chetan and Csípő, Tamás and Lipécz, Ágnes and Tabák, Ádám and Csiszar, Anna and Ungvári, Zoltán István (2021) Obesity-induced cognitive impairment in older adults: a microvascular perspective. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 320 (2). H740-H761. ISSN 0363-6135
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Abstract
Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction, and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Aging; endothelial dysfunction; metabolic syndrome; senescence; Neurovascular coupling; |
| Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC628 Obesity / obezitológia, elhízástudomány |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 03 Feb 2022 14:22 |
| Last Modified: | 03 Feb 2022 14:22 |
| URI: | http://real.mtak.hu/id/eprint/137139 |
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