Harmati, Mária and Bukva, Mátyás and Böröczky, Timea and Buzás, Krisztina and Gyukity-Sebestyén, Edina (2021) The role of the metabolite cargo of extracellular vesicles in tumor progression. CANCER AND METASTASIS REVIEWS. ISSN 0167-7659
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Abstract
Metabolomic reprogramming in tumor and stroma cells is a hallmark of cancer but understanding its effects on the metabolite composition and function of tumor-derived extracellular vesicles (EVs) is still in its infancy. EVs are membrane-bound sacs with a complex molecular composition secreted by all living cells. They are key mediators of intercellular communication both in normal and pathological conditions and play a crucial role in tumor development. Although lipids are major components of EVs, most of the EV cargo studies have targeted proteins and nucleic acids. The potential of the EV metabolome as a source for biomarker discovery has gained recognition recently, but knowledge on the biological activity of tumor EV metabolites still remains limited. Therefore, we aimed (i) to compile the list of metabolites identified in tumor EVs isolated from either clinical specimens or in vitro samples and (ii) describe their role in tumor progression through literature search and pathway analysis.
| Item Type: | Article |
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| Additional Information: | Funding Agency and Grant Number: ELKH Biological Research Center; National Research, Development and Innovation Fund [GINOP-2.2.1-15-2017-00052]; University of Szeged, Faculty of Medicine, Szent-Gyorgyi Albert Research Fund; New National Excellence Program of the Ministry for Innovation and Technology from the National Research, Development and Innovation Fund [UNKP-20-3] Funding text: Open access funding provided by ELKH Biological Research Center. This study was supported by the following research grants: GINOP-2.2.1-15-2017-00052, UNKP-20-3-New National Excellence Program of the Ministry for Innovation and Technology from the National Research, Development and Innovation Fund; University of Szeged, Faculty of Medicine, Szent-Gyorgyi Albert Research Fund (2021). |
| Uncontrolled Keywords: | EXPRESSION; METABOLITES; CANCER; proteomics; FATTY-ACID; HYPOXIA; CELL LUNG-CANCER; INTERCELLULAR COMMUNICATION; Exosomes; Extracellular vesicles; POTENTIAL BIOMARKERS; ALPHA-AMINOADIPATE; |
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 03 Feb 2022 14:51 |
| Last Modified: | 03 Feb 2022 14:51 |
| URI: | http://real.mtak.hu/id/eprint/137252 |
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