Tálas, András and Simon, Dorottya Anna and Kulcsár, Péter István and Varga, Éva and Krausz, Sarah and Welker, Ervin (2021) BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors. NATURE COMMUNICATIONS, 12 (1). ISSN 2041-1723
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Official URL: http://doi.org/10.1038/s41467-021-26461-y
| Item Type: | Article |
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| Additional Information: | Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary School of Ph.D. Studies, Semmelweis University, Budapest, Hungary Gene Design Ltd., Szeged, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary Biospiral-2006 Ltd., Szeged, Hungary School of Ph.D. Studies, University of Szeged, Szeged, Hungary Institute of Biochemistry, Biological Research Centre, Szeged, Hungary Export Date: 17 November 2021 Correspondence Address: Tálas, A.; Institute of Enzymology, Hungary; email: talas.andras@ttk.hu Correspondence Address: Welker, E.; Institute of Enzymology, Hungary; email: welker.ervin@ttk.hu Funding details: Semmelweis Egyetem Funding details: Hungarian Scientific Research Fund, OTKA, 2018-1.1.1-MKI-2018-00167, K128188, K134968, VEKOP-2.1.7-15-2016-00393, ÚNKP-20-5-SE-20 Funding details: National Research, Development and Innovation Office, EFOP-3.6.3-VEKOP-16-2017-00009 Funding text 1: We thank Dr. György Váradi and the FACS core facility for their valuable help with cell sorting. We thank Vivien Karl, Ildikó Szűcsné Pulinka, Judit Szűcs, Lilla Burkus and Judit Kálmán for their excellent technical assistance. We thank Antal Nyeste and Zsuzsa Bartos for their invaluable help and for Vanessza Laura Végi for proofreading the manuscript. The project was supported by grants K128188 and K134968 to E.W and PD134858 to P.I.K. from the Hungarian Scientific Research Fund (OTKA) and P.I.K. by 2018-1.1.1-MKI-2018-00167 and by ÚNKP-20-5-SE-20, and D.S. by VEKOP-2.1.7-15-2016-00393 from the National Research, Development and Innovation Office. P. I. K. is a recipient of the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/764/ 20). S.L.K was supported by grant EFOP-3.6.3-VEKOP-16-2017-00009 from the Higher Education Institutional Excellence Program of the Semmelweis University. |
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3020 Biophysics / biofizika |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 08 Feb 2022 17:24 |
| Last Modified: | 08 Feb 2022 17:24 |
| URI: | http://real.mtak.hu/id/eprint/137510 |
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