Hegedüs, Panna and Heckenast, Júlia and Hangya, Balázs (2021) Differential recruitment of ventral pallidal e-types by behaviorally salient stimuli during Pavlovian conditioning. ISCIENCE, 24 (4). ISSN 2589-0042
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Abstract
The ventral pallidum (VP) is interfacing striatopallidal and limbic circuits, conveying information about salience and valence crucial to adjusting behavior. However, how VP neuron populations with distinct electrophysiological properties (e-types) represent these variables is not fully understood. Therefore, we trained mice on probabilistic Pavlovian conditioning while recording the activity of VP neurons. Many VP neurons responded to punishment (54%), reward (48%), and outcome-predicting auditory stimuli (32%), increasingly differentiating distinct outcome probabilities through learning. We identified e-types based on the presence of bursts or fast rhythmic discharges and found that non-bursting, non-rhythmic neurons were the most sensitive to reward and punishment. Some neurons exhibited distinct responses of their bursts and single spikes, suggesting a multiplexed coding scheme in the VP. Finally, we demonstrate synchronously firing neuron assemblies, particularly responsive to reinforcing stimuli. These results suggest that electrophysiologically defined e-types of the VP differentially participate in transmitting reinforcement signals during learning. © 2021 The Author(s)
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| Additional Information: | Lendület Laboratory of Systems Neuroscience, Institute of Experimental Medicine, Budapest, 1083, Hungary János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, 1085, Hungary Cited By :1 Export Date: 1 February 2022 Correspondence Address: Hangya, B.; Lendület Laboratory of Systems Neuroscience, Hungary; email: hangya.balazs@koki.hu Funding details: European Research Council, ERC, 715043 Funding details: Semmelweis Egyetem, EFOP-3.6.3, VEKOP- 16-2017-00009 Funding details: Magyar Tudományos Akadémia, MTA, LP2015-2/2015 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K135561, KH125294 Funding details: Ministry for Innovation and Technology, ÚNKP-20-3-II Funding text 1: We thank Katalin Lengyel for her help with histology and Katalin Sviatk? and Sergio Mart?nez-Bellver for their help with behavioral training. We acknowledge the help of L?szl? Barna and the Nikon Center of Excellence at the Institute of Experimental Medicine, Nikon Europe, Nikon Austria, and Auro-Science Consulting for kindly providing microscopy support. We thank Mackenzie Mathis and anonymous authors for open access science art at SciDraw (accessible at https://doi.org/10.5281/zenodo.3925907 and https://doi.org/10.5281/zenodo.3925927). This work was supported by the ?Lend?let? Program of the Hungarian Academy of Sciences (LP2015-2/2015), NKFIH KH125294, NKFIH K135561, and the European Research Council Starting Grant no. 715043 to B.H.; the Kerpel-Fronius Talent Support Program of Semmelweis University (EFOP-3.6.3.-VEKOP-16-2017-00009); and the New National Excellence Program of the Ministry of Innovation and Technology (?NKP-20-3-II) to P.H. B.H. developed the idea and conceptualized the manuscript. P.H. and J.H. performed the experiments. P.H. B.H. and J.H. performed data analysis. P.H. generated the figures. B.H. and P.H. wrote the manuscript with input from J.H. The authors declare no competing financial interests. Funding text 2: We thank Katalin Lengyel for her help with histology and Katalin Sviatkó and Sergio Martínez-Bellver for their help with behavioral training. We acknowledge the help of László Barna and the Nikon Center of Excellence at the Institute of Experimental Medicine, Nikon Europe, Nikon Austria, and Auro-Science Consulting for kindly providing microscopy support. We thank Mackenzie Mathis and anonymous authors for open access science art at SciDraw (accessible at https://doi.org/10.5281/zenodo.3925907 and https://doi.org/10.5281/zenodo.3925927 ). This work was supported by the “Lendület” Program of the Hungarian Academy of Sciences ( LP2015-2/2015 ), NKFIH KH125294 , NKFIH K135561 , and the European Research Council Starting Grant no. 715043 to B.H.; the Kerpel-Fronius Talent Support Program of Semmelweis University (EFOP-3.6.3.-VEKOP- 16-2017-00009 ); and the New National Excellence Program of the Ministry of Innovation and Technology (ÚNKP-20-3-II) to P.H. |
| Uncontrolled Keywords: | Behavioral neuroscience; cellular neuroscience; Cellular physiology; |
| Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 04 Apr 2022 12:38 |
| Last Modified: | 04 Apr 2022 12:42 |
| URI: | http://real.mtak.hu/id/eprint/140272 |
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