Huygens synchronization of medial septal pacemaker neurons generates hippocampal theta oscillation

Kocsis, Barnabás and Martínez-Bellver, Sergio and Fiáth, Richárd and Domonkos, Andor and Tóthné Sviatkó, Katalin and Schlingloff, Dániel and Freund, Tamás and Ulbert, István and Káli, Szabolcs and Varga, Viktor and Hangya, Balázs (2022) Huygens synchronization of medial septal pacemaker neurons generates hippocampal theta oscillation. CELL REPORTS, 40 (5). No. 111149. ISSN 2211-1247

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Episodic learning and memory retrieval are dependent on hippocampal theta oscillation, thought to rely on the GABAergic network of the medial septum (MS). To test how this network achieves theta synchrony, we recorded MS neurons and hippocampal local field potential simultaneously in anesthetized and awake mice and rats. We show that MS pacemakers synchronize their individual rhythmicity frequencies, akin to coupled pendulum clocks as observed by Huygens. We optogenetically identified them as parvalbumin-expressing GABAergic neurons, while MS glutamatergic neurons provide tonic excitation sufficient to induce theta. In accordance, waxing and waning tonic excitation is sufficient to toggle between theta and non-theta states in a network model of single-compartment inhibitory pacemaker neurons. These results provide experimental and theoretical support to a frequency-synchronization mechanism for pacing hippocampal theta, which may serve as an inspirational prototype for synchronization processes in the central nervous system from Nematoda to Arthropoda to Chordate and Vertebrate phyla.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában > R850-854 Experimental medicine / kisérleti orvostudomány
R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
Depositing User: MTMT SWORD
Date Deposited: 17 Aug 2022 09:36
Last Modified: 17 Aug 2022 09:36

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