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Steroid concentrations in atopic dermatitis patients: Reduced plasma DHEAS and increased cortisone levels.

Mihály, J. and Sonntag, D. and Krebiehl, G. and Szegedi, Ágnes and Töröcsik, D. and Rühl, R. (2014) Steroid concentrations in atopic dermatitis patients: Reduced plasma DHEAS and increased cortisone levels. The British journal of dermatology. ISSN 1365-2133

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Abstract

Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease, which is characterized by a disrupted epidermal barrier function present both in affected skin and in non-affected skin. Mainly glucocorticosteroids were used in topical and systemic atopy treatments because of their potent anti-inflammatory effects, unfortunately with strong side effects. In this study we determined that 2 out of 16 steroids were significantly different in healthy volunteers vs AD-patients. Cortisone, which is higher in AD-patients plasma, is a direct precursor of the bioactive corticosteroid cortisol, which just displays a higher tendency and is known for its potent anti-inflammatory effects. In addition a tendency of reduced levels of the anti-inflammatory ER ligand estrone was found in AD-patients. DHEA is a precursor of testosterone, its levels just display a lower tendency in male AD-patients, while its sulfonation metabolite DHEAS is lower in male and female AD-patients. We found and conclude that altered steroid levels in the plasma of AD-patients indicate altered vitamin D signaling (based on reduced DHEA sulfonation) and increased feedback for anti-inflammatory signaling (increased levels of cortisone) present in AD-patients. This article is protected by copyright. All rights reserved.

Item Type: Article
Subjects: R Medicine / orvostudomány > RL Dermatology / bőrgyógyászat
Depositing User: Dr Daniel Torocsik
Date Deposited: 17 Sep 2014 12:53
Last Modified: 14 Mar 2015 02:25
URI: http://real.mtak.hu/id/eprint/15123

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