Blocking the Increase of Intracellular Deuterium Concentration Prevents the Expression of Cancer-Related Genes, Tumor Development, and Tumor Recurrence in Cancer Patients

Kovács, Beáta Zs. and Puskás, László G. and Nagy, Lajos I. and Papp, András and Gyöngyi, Zoltán and Fórizs, István and Czuppon, György (2022) Blocking the Increase of Intracellular Deuterium Concentration Prevents the Expression of Cancer-Related Genes, Tumor Development, and Tumor Recurrence in Cancer Patients. CANCER CONTROL, 29. ISSN 1073-2748

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The possible role of the naturally occurring deuterium in the regulation of cell division was first described in the 1990s. To investigate the mechanism of influence of deuterium (D) on cell growth, expression of 236 cancer-related and 536 kinase genes were tested in deuterium-depleted (40 and 80 ppm) and deuterium-enriched (300 ppm) media compared to natural D level (150 ppm). Among genes with expression changes exceeding 30% and copy numbers over 30 (124 and 135 genes, respectively) 97.3% of them was upregulated at 300 ppm D-concentration. In mice exposed to chemical carcinogen, one-year survival data showed that deuterium-depleted water (DDW) with 30 ppm D as drinking water prevented tumor development. One quarter of the treated male mice survived 344 days, the females 334 days, while one quarter of the control mice survived only 188 and 156 days, respectively. In our human retrospective study 204 previously treated cancer patients with disease in remission, who consumed DDW, were followed. Cumulative follow-up time was 1024 years, and average follow-up time per patient, 5 years (median: 3.6 years). One hundred and fifty-six patients out of 204 (77.9%) did not relapse during their 803 years cumulative follow-up time. Median survival time (MST) was not calculable due to the extremely low death rate (11 cancer-related deaths, 5.4% of the study population). Importantly, 8 out of 11 deaths occurred several years after stopping DDW consumption, confirming that regular consumption of DDW can prevent recurrence of cancer. These findings point to the likely mechanism in which consumption of DDW keeps D-concentration below natural levels, preventing the D/H ratio from increasing to the threshold required for cell division. This in turn can serve as a key to reduce the relapse rate of cancer patients and/or to reduce cancer incidence in healthy populations.

Item Type: Article
Additional Information: HYD LLC for Cancer Research and Drug Development, Budapest, Hungary AVIDIN Ltd, Szeged, Hungary Department of Public Health, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Public Health, Medical School, University of Pécs, Pécs, Hungary Institute for Geological and Geochemical Research (IGGR), Research Centre for Astronomy and Earth Sciences, Eötvös Loránt Research Network, Budapest, Hungary Export Date: 31 January 2022 CODEN: CACOF
Uncontrolled Keywords: Metabolism; Gene Expression; cancer recurrence; cancer prevention; NanoString technology; D/H ratio; anticancer drug development; deuterium-depleted water (DDW); median survival time (MST); production of metabolic water;
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
Depositing User: MTMT SWORD
Date Deposited: 09 Nov 2022 10:04
Last Modified: 09 Nov 2022 10:04

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