ODC mRNA as a prognostic factor for predicting recurrence in meningiomas

Klekner, A. and Röhn, A. G. and Schillinger, G. and Schröder, R. and Klug, N. and Ernestus, R. I. (2001) ODC mRNA as a prognostic factor for predicting recurrence in meningiomas. Journal of Neuro-Oncology, 53 (1). pp. 67-75. ISSN 0167-594X

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In proliferating neoplastic cells, activity of the enzyme ornithine decarboxylase (ODC) increases. Among other brain tumors, ODC activation could also be observed in meningiomas. In the present study, we have investigated ODC gene expression in primary and recurrent meningiomas at the transcriptional level. ODC mRNA (messenger ribonucleic acid), ODC activity, number of mitoses, and Ki-67 index as a marker for nuclear proliferation were quantified in three different groups of meningiomas: tumors without recurrence in a 8.4 years median follow-up period, tumors with recurrence within a median follow-up of 3.0 years, and their corresponding recurrent tumors. ODC mRNA level was significantly higher in meningiomas with later recurrence as compared to meningiomas without recurrence (p < or = 0.01), whereas it declined in the recurrences of the second group (p < or = 0.001). In contrast, ODC activity showed no difference between the two groups of primary tumors, but a significant increase of enzyme activity could be observed in the recurrences as compared to the correponding primary tumors (p < or = 0.001). Likewise,an increase of the Ki-67 index could be detected in the recurrent group (p < or = 0.001). These results suggest that ODC mRNA may represent a prognostic factor for predicting recurrence in meningiomas.

Item Type: Article
Uncontrolled Keywords: meningiomas, ornithine decarboxylase (ODC), mRNA, Ki-67, mitoses, recurrence, prognosis
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
Depositing User: Dr. Álmos Klekner
Date Deposited: 26 Sep 2014 18:55
Last Modified: 26 Sep 2014 18:55

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