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NRF2-ome: an integrated web resource to discover protein interaction and regulatory networks of NRF2.

Türei, Dénes and Papp, Diána and Fazekas, Dávid and Földvári-Nagy, László and Módos, Dezső and Lenti, Katalin and Csermely, Péter and Korcsmáros, Tamás (2013) NRF2-ome: an integrated web resource to discover protein interaction and regulatory networks of NRF2. Oxidative Medicine and Cellular Longevity, 2013. p. 737591. ISSN 1942-0994

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Abstract

NRF2 is the master transcriptional regulator of oxidative and xenobiotic stress responses. NRF2 has important roles in carcinogenesis, inflammation, and neurodegenerative diseases. We developed an online resource, NRF2-ome, to provide an integrated and systems-level database for NRF2. The database contains manually curated and predicted interactions of NRF2 as well as data from external interaction databases. We integrated NRF2 interactome with NRF2 target genes, NRF2 regulating TFs, and miRNAs. We connected NRF2-ome to signaling pathways to allow mapping upstream NRF2 regulatory components that could directly or indirectly influence NRF2 activity totaling 35,967 protein-protein and signaling interactions. The user-friendly website allows researchers without computational background to search, browse, and download the database. The database can be downloaded in SQL, CSV, BioPAX, SBML, PSI-MI, and in a Cytoscape CYS file formats. We illustrated the applicability of the website by suggesting a posttranscriptional negative feedback of NRF2 by MAFG protein and raised the possibility of a connection between NRF2 and the JAK/STAT pathway through STAT1 and STAT3. NRF2-ome can also be used as an evaluation tool to help researchers and drug developers to understand the hidden regulatory mechanisms in the complex network of NRF2.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3015 Molecular biology / molekuláris biológia
Depositing User: Dr. Tamas Korcsmaros
Date Deposited: 30 Sep 2014 14:06
Last Modified: 30 Sep 2014 14:06
URI: http://real.mtak.hu/id/eprint/17328

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