Closed-chest occlusion of the left anterior descending artery in swine infarction model

Kőrösi, Dénes and Vorobcsuk, András and Fajtai, Dániel and Tátrai, Ottó and Bodor, Emőke and Garamvölgyi, Rita (2023) Closed-chest occlusion of the left anterior descending artery in swine infarction model. ACTA AGRARIA KAPOSVÁRIENSIS, 27 (1-2). pp. 77-85. ISSN 1418-1789

Preview

Text 77_85_Korosietal_2023_01.pdf Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (394kB) | Preview

Abstract

Pigs have played a significant role in biological and medical research for many years. In the case of non-rodent models, pigs are the primary choices as experimental animals in the cardiovascular studies. Accumulating data indicate that the closed-chest coronary balloon-occlusion technique is one of the most successful method for creating ischemic heart failure (HF). However, consistent and thoroughly characterized large animal models of HF are a critical translational tool for drug development and toxicology. The knowledge of the different catheterization protocols is crucial to ensure a suitable animal model which can serve as a human-related preclinical validation process. Therefore it is essential to follow an optimized and standardized experimental protocol on a homogenous animal population, which help to obtain reliable and useful data for the translational large animal research programs.

Actions (login required)

Edit Item