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Synthesis of Deprenyl-like nitroxide free radicals and their diamagnetic derivatives

Sár, Cecília and Kálai, Tamás and Jekö, József and Hideg, Kálmán (2012) Synthesis of Deprenyl-like nitroxide free radicals and their diamagnetic derivatives. ARKIVOC (5). pp. 47-59. ISSN 1551-7012, ESSN: 1551-7004

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Abstract

Synthesis of paramagnetically modified deprenyl and oxotremorine is reported. Starting from 5- and 6-membered 2,5-disubstituted nitrones (1, 6) or 4-phenyl-2,5,5-trimethyl-1H-pyrroline 1-oxide (11) deprenyl or oxotremorine like nitroxides were synthesized via Grignard reactions. The corresponding pre-nitroxides with propargylamine structure were achieved by reduction of nitroxides followed by methylation.

Item Type: Article
Subjects: Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia
Depositing User: Dr. Tamás Kálai
Date Deposited: 11 Jan 2015 18:58
Last Modified: 11 Jan 2015 18:58
URI: http://real.mtak.hu/id/eprint/20276

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