C1 inhibitor: quantification and purification.

Varga, Lilian and Dobó, József (2014) C1 inhibitor: quantification and purification. In: The Complement System. Humana Press, New York, pp. 189-205.

[img] Text
Restricted to Registered users only

Download (1MB) | Request a copy


C1 inhibitor is a multipotent serpin capable of inhibiting the classical and the lectin pathways of complement, the fibrinolytic system, and contact/kinin system of coagulation. Deficiency of C1 inhibitor manifest as hereditary angioedema (HAE), an autosomal dominant hereditary disease. Measuring the C1 inhibitor level is of vital importance for the diagnosis of HAE and also for monitoring patients receiving C1 inhibitor for therapy. Determination of the antigenic C1 inhibitor level by the radial immunodiffusion (RID) technique is described in detail in this chapter. The presented purification method of plasma C1 inhibitor is primarily based on its high carbohydrate content and its affinity to the lectin jacalin.

Item Type: Book Section
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: MTMT SWORD
Date Deposited: 12 Jan 2015 14:47
Last Modified: 12 Jan 2015 14:47

Actions (login required)

Edit Item Edit Item