Preparation of resveratrol-loaded nanoporous silica materials with different structures

Popova, Margarita and Szegedi, Ágnes and Mavrodinova, Vesselina and Novak Tušar, Nataša and Mihály, Judith and Klébert, Szilvia and Benbassat, Niko and Yoncheva, Krassimira (2014) Preparation of resveratrol-loaded nanoporous silica materials with different structures. Journal of Solid State Chemistry, 219. pp. 37-42. ISSN 0022-4596

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Abstract

Solid, nanoporous silica-based spherical mesoporous MCM-41 and KIL-2 with interparticle mesoporosity as well as nanosized zeolite BEA materials differing in morphology and pore size distribution, were used as carriers for the preparation of resveratrol-loaded delivery systems. Two preparation methods have been applied: (i) loading by mixing of resveratrol and mesoporous carrier in solid state and (ii) deposition in ethanol solution. The parent and the resveratrol loaded carriers were characterized by XRD, TEM, N2 physisorption, thermal analysis, and FT-IR spectroscopy. The influence of the support structure on the adsorption capacity and the release kinetics of this poorly soluble compound were investigated. Our results indicated that the chosen nanoporous silica supports are suitable for stabilization of trans-resveratrol and reveal controlled release and ability to protect the supported compound against degradation regardless of loading method. The solid-state dry mixing appears very effective for preparation of drug formulations composed of poorly soluble compound.

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