Reliability and Validity of the international cooperative ataxia rating scale: A study in 156 spinocerebellar ataxia patients

Schmitz-Hübsch, Tanja and Tezenas du Montcel, Sophie and Balikó, László and Boesch, Sylvia and Bonato, Sara and Fancellu, Roberto and Giunti, Paola and Globas, Christoph and Kang, Jun-Suk and Kremer, Berry and Mariotti, Caterina and Melegh, Béla and Rakowicz, Maria and Rola, Rafal and Romano, Sylvie and Schöls, Lodger and Szymanski, Sandra and van de Warrenburg, Bart P. C. and Zdzienicka, Elzbieta and Durr, Alexandra and Klockgether, Thomas (2006) Reliability and Validity of the international cooperative ataxia rating scale: A study in 156 spinocerebellar ataxia patients. MOVEMENT DISORDERS, 21 (5). pp. 969-704. ISSN 0885-3185

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Abstract To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test-retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials. Copyright (c) 2006 Movement Disorder Society.

Item Type: Article
Uncontrolled Keywords: ICARS; spinocerebellar ataxia; clinical assesment; Zala Megyei Kórház tudományos közleményei
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
Depositing User: xGabriella xBeke
Date Deposited: 09 Jun 2015 12:29
Last Modified: 09 Jun 2015 12:29

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