LADA type diabetes, celiac diasease, cerebellar ataxia and stiff person syndrome. A rare association of autoimmune disorders.

Soos, Z. and Salamon, M. and Erdei, K. and Kaszas, N. and Folyovich, András and Szűcs, Anna and Arányi, Zsuzsanna and Winkler, Gábor (2014) LADA type diabetes, celiac diasease, cerebellar ataxia and stiff person syndrome. A rare association of autoimmune disorders. IDEGGYÓGYÁSZATI SZEMLE / CLINICAL NEUROSCIENCE, 67 (5-6). pp. 205-209. ISSN 0019-1442


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Celiac disease--in its typical form--is a chronic immune-mediated enteropathy with typical clinical symptoms that develops against gliadin content of cereal grains, and is often associated with other autoimmune diseases. In cases of atypical manifestation classic symptoms may be absent or mild, and extra-intestinal symptoms or associated syndromes dominate clinical picture. The authors present a longitudinal follow-up of such a case. A 63-years old woman was diagnosed with epilepsy at the age of 19, and with progressive limb ataxia at the age of 36, which was initially thought to be caused by cerebellar atrophy, later probably by stiff person syndrome. At the age 59, her diabetes mellitus manifested with type 2 diabetic phenotype, but based on GAD positivity later was reclassified as type 1 diabetes. Only the last check-up discovered the celiac disease, retrospectively explaining the entire disease course and neurological symptoms. By presenting this case, the authors would like to draw attention to the fact that one should think of the possibility of celiac disease when cerebellar ataxia, progressive neurological symptoms and diabetes are present at the same time. An early diagnosis may help to delay the progression of disease and help better treatment.

Item Type: Article
Uncontrolled Keywords: Stiff-Person Syndrome/complications/*diagnosis/immunology; Middle Aged; Humans; Follow-Up Studies; Female; Epilepsy/diagnosis/drug therapy; Duodenum/pathology; Diagnosis, Differential; Diabetes Mellitus, Type 1/*diagnosis/immunology; Diabetes Complications/*diagnosis/immunology; Cerebellar Ataxia/complications/*diagnosis/immunology; Celiac Disease/complications/*diagnosis/immunology/pathology; *Autoimmunity; Autoantibodies/blood; Aged; Adult
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: MTMT SWORD
Date Deposited: 14 Jul 2015 05:28
Last Modified: 12 Jan 2016 14:45

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