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Hemocompatibility and Biomedical Potential of Poly(Gallic Acid) Coated Iron Oxide Nanoparticles for Theranostic Use

Szekeres, Márta and Illés, Erzsébet and Janko, Christina and Farkas, Katalin and Tóth, Ildikó Y. and Nesztor, Dániel and Zupkó, István and Földesi, Imre and Alexiou, Christoph and Tombácz, Etelka (2015) Hemocompatibility and Biomedical Potential of Poly(Gallic Acid) Coated Iron Oxide Nanoparticles for Theranostic Use. Journal of Nanomedicine and Nanotechnology, 6. p. 252. ISSN ISSN: 2157-7439

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Abstract

Polyacid covered core-shell iron oxide nanoparticles were designed for potential use in biomedicine with special attention to theranostics - magnetic resonance imaging (MRI), magnetic hyperthermia and magnetic drug targeting. The magnetite nanoparticles coated with a gallic acid shell polymerized in situ on the nanoparticle surface (PGA@MNPs) were tested for hemocompatibility in blood, sedimentation rate, blood smear and blood cell viability experiments and for antioxidant capacity in Jurkat cells in the presence of H2O2 as reactive oxygen species. No signs of interaction of the nanoparticles with whole blood cells were found. In addition, the PGA@MNPs reduced significantly the oxidative stress mediated by H2O2 supporting earlier findings of MTT tests, namely, the improvement of cell viability in their presence. The in vitro tests revealed that PGA@MNPs are not only biocompatible but also bioactive. Preliminary experiments revealed that the nanoparticles are especially efficient MRI and magnetic hyperthermia agents. The r2 relaxivity was found to be one of the highest among published values (387 mM-1s-1) and they possess a relatively significant specific absorption rate (SAR) value of 11 W/g magnetite.

Item Type: Article
Subjects: Q Science / természettudomány > QD Chemistry / kémia
Depositing User: Dr. Etelka Tombácz
Date Deposited: 07 Aug 2015 21:51
Last Modified: 07 Aug 2015 21:51
URI: http://real.mtak.hu/id/eprint/25796

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