Resveratrol enhances exercise training responses in rats selectively bred for high running performance

Hart, Nikolett and Sarga, Linda and Csende, Zsolt and Koltai, Erika and Koch, Lauren G. and Britton, Steven L. and Davies, Kelvin J. A. and Kouretas, Dimitris and Wessner, Barbara and Radak, Zsolt (2013) Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 61. pp. 53-9. ISSN 1873-6351

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High Capacity Runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12 weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p<0.05). The changes in mitochondrial fission/fusion and Lon protease/HSP78 levels suggest that exercise training does not significantly induce damage of proteins. Moreover, neither exercise training nor resveratrol supplementation altered the content of protein carbonyls. Changes in the levels of forkhead transcription factor 1 and SIRT4 could suggest increased fat utilization and improved insulin sensitivity. These data indicate, that resveratrol supplementation enhances aerobic performance due to the activation of the AMPK-SIRT1-PGC-1α pathway.

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Depositing User: Dr. Erika Koltai
Date Deposited: 24 Sep 2015 08:33
Last Modified: 01 Nov 2017 00:15

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