Parameter optimization of H∞ controller designed for tumor growth in the light of physiological aspects

Sápi, Johanna and Drexler, Dániel András and Kovács, Levente (2013) Parameter optimization of H∞ controller designed for tumor growth in the light of physiological aspects. In: CINTI 2013 : Proceeding of the 14th IEEE International Symposium on Computational Intelligence and Informatics. IEEE Hungary Section, Budapest, pp. 19-24. ISBN 978-1-4799-0194-4

Preview

Text 3_cinti2013.pdf Download (1MB) | Preview

Abstract

According to the fact that cancer diseases are leading causes of death all around the world, development of cancer fighting therapies is necessary. Beside the medical knowledge, there is an extra need for engineering approach to solve this complex problem. The aim of this paper is to design controller for tumor growth under angiogenic inhibition, which on the one hand minimizes the input signal as far as possible (in order to have less side effects and greater cost-effectiveness) and on the other hand results in appropriately low tumor volume. Since the model contains uncertainties and measurement noise, the controller was designed using modern robust control methodology. Choosing of the ideal system and the weighting functions were done in the light of physiological aspects.

Actions (login required)

Edit Item