Repository of the Academy's Library

Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise. Implications for Structure-Based Drug Design

Menyhárd, D.K. and Keserű, György Miklós and Náray-Szabó, Gábor (2009) Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise. Implications for Structure-Based Drug Design. Current Computer-Aided Drug Design, 5 (4). pp. 264-279.

[img]
Preview
PDF
Calmodulin.pdf

Download (3720Kb)

Abstract

Calmodulin plays a role in several life processes, its flexibility allows binding of a number of different ligands from small molecules to amphiphilic peptide helices and proteins. Through the diversity of its functions, it is quite difficult to find new drugs, which bind to calmodulin as a target. We present available structural information on the protein, obtained by X-ray diffraction, nuclear magnetic resonance spectroscopy and molecular modeling and try to derive some conclusions on structureactivity relationships.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3015 Molecular biology / molekuláris biológia
R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan
Depositing User: Prof Gábor Náray-Szabó
Date Deposited: 07 Feb 2012 08:49
Last Modified: 27 Dec 2013 07:34
URI: http://real.mtak.hu/id/eprint/2828

Actions (login required)

View Item View Item