Platelet Reactivity: Is There a Role to Switch?

Aradi, Dániel and Merkely, Béla and Komócsi, András (2015) Platelet Reactivity: Is There a Role to Switch? Progress In Cardiovascular Diseases, 58 (3). pp. 278-284. ISSN 0033-0620

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Antiplatelet agents are essential to prevent thrombotic events in patients with coronary artery disease, especially in those with acute coronary syndrome or undergoing percutaneous coronary intervention (PCI). However, the benefits of antiplatelet therapy always come at a price of increased risk for bleeding, and the clinical values of antiplatelet strategies depend on this characteristic benefit/risk ratio. Platelet function testing aiming at determining an individual’s response to the administered agent was hoped to help balance bleeding and thrombosis in order to maximize benefit/risk ratio. However, randomized trials failed to demonstrate an improved clinical outcome of a platelet function-based treatment selection and consequently platelet function testing has not become a routine part of the management of antiplatelet therapies. This review aims to discuss results and shortcomings of available trials and registries regarding the potential role of platelet reactivity testing in guiding antiplatelet treatment selection in patients undergoing PCI.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: Dr Dániel Aradi
Date Deposited: 27 Sep 2015 10:47
Last Modified: 04 Apr 2016 11:36

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