On the role of 4-hydroxynonenal in health and disease

Csala, Miklós and Kardon, Tamás and Legeza, Balázs and Lizák, Beáta and Mandl, József and Margittai, Éva and Puskás, Ferenc and Száraz, Péter and Szelényi, Péter and Bánhegyi, Gábor (2015) On the role of 4-hydroxynonenal in health and disease. BIOCHIMICA ET BIOPHYSICA ACTA, 1852 (5). pp. 826-838. ISSN 0006-3002

Text BBA DIS_2015.pdf Restricted to Repository staff only Download (756kB) | Request a copy

Abstract

Polyunsaturated fatty acids are susceptible to peroxidation and they yield various degradation products, including the main α,β-unsaturated hydroxyalkenal, 4-hydroxy-2,3-trans-nonenal (HNE) in oxidative stress. Due to its high reactivity, HNE interacts with various macromolecules of the cell, and this general toxicity clearly contributes to a wide variety of pathological conditions. In addition, growing evidence suggests a more specific function of HNE in electrophilic signaling as a second messenger of oxidative/electrophilic stress. It can induce antioxidant defense mechanisms to restrain its own production and to enhance the cellular protection against oxidative stress. Moreover, HNE-mediated signaling can largely influence the fate of the cell through modulating major cellular processes, such as autophagy, proliferation and apoptosis. This review focuses on the molecular mechanisms underlying the signaling and regulatory functions of HNE. The role of HNE in the pathophysiology of cancer, cardiovascular and neurodegenerative diseases is also discussed.

Actions (login required)

Edit Item