Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

Mavrodinova, Vesselina and Popova, Margarita and Yoncheva, Krassimira and Mihály, Judith and Szegedi, Ágnes (2015) Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 458. pp. 32-38. ISSN 0021-9797


Download (785kB) | Preview


Hypothesis: A new simplified procedure for encapsulation of antibacterial silver nanoparticles by Solid-state Ion Exchange (SSIE) procedure over zeolite Y, followed by deposition of sulfadiazine (SD) by dry mixing was examined for the preparation of topical antibacterial formulations. The ion-exchange and adsorptive properties of the zeolite matrix were utilized for the bactericidal Ag deposition and loading of antibiotic sulfadiazine. Experiments: Assessment of the encapsulation efficiency of both active components loaded by solid and liquid deposition methods was made by X-ray diffraction, TEM, FT-IR spectroscopy and thermogravimetric analysis (TGA). SD release kinetics was also determined. Findings: Sustained delivery of sulfadiazine has been observed from the Ag-modified zeolites compared to the parent HY material. It was found that if SD was loaded in solution, part of the zeolite silver ions was released and interacted with SD, forming AgSD. By solid-state SD deposition, the reaction between the drug and the silver was restricted within the limits of inter-atomic interaction, and total but prolonged drug release occurred. © 2015 Published by Elsevier Inc.

Item Type: Article
Uncontrolled Keywords: transmission electron microscopy; Thermogravimetry; solid state; priority journal; infrared spectroscopy; drug structure; ARTICLE; Zeolite Y; zeolite; unclassified drug; Sulfadiazine; silver nanoparticle; Ion exchange; Zeolite-Y; Solid state ion exchange; Simplified procedure; Silver nanoparticles; Interatomic interactions; Encapsulation efficiency; Adsorptive properties; X ray diffraction; Thermogravimetric analysis; SILVER; metal ions; IONS; encapsulation; DEPOSITION; Zeolite Y carrier; Sulfadiazine encapsulation; Solid state Ag ion-exchange; Drug release
Subjects: Q Science / természettudomány > QD Chemistry / kémia
Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia
Depositing User: MTMT SWORD
Date Deposited: 12 Oct 2015 14:24
Last Modified: 12 Oct 2015 14:24

Actions (login required)

Edit Item Edit Item