Kardos, Márton and Kiss, Loránd and Fülöp, Ferenc (2015) Stereocontrolled synthesis of difunctionalized azetidinones and β2,3-amino acid derivatives from cyclodienes by ring opening and cross-metathesis reactions. Asian Journal of Organic Chemistry. pp. 1155-1159.
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Abstract
A stereocontrolled approach to novel highly functionalized 3,4-disubstituted azetidin-2-ones and β2,3-amino acid derivatives from readily available cycloalkadienes was achieved. The syntheses involved 1,3-dipolar cycloaddition of chlorosulfonyl isocyanate, followed by ring opening metathesis of the unsaturated bi- or tricyclic β-lactams, and cross-metathesis of the resulting divinyl-substituted azetidinones. The substituted lactams were subsequently transformed by heteroring opening into the corresponding functionalized acyclic β2,3-amino acid derivatives.
Item Type: | Article |
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Subjects: | Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia |
Depositing User: | Dr Loránd Kiss |
Date Deposited: | 30 Dec 2015 19:25 |
Last Modified: | 30 Dec 2015 19:26 |
URI: | http://real.mtak.hu/id/eprint/31595 |
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