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Stimulus-dependent muscarinic effects on evoked unit activity in the rat barrel cortex

Farkas, Tamás and Kóródi, Katalin and Toldi, József (1996) Stimulus-dependent muscarinic effects on evoked unit activity in the rat barrel cortex. Neuroscience Letters, 212 (1). pp. 61-64. ISSN 0304-3940

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Abstract

The cerebral cortex receives a prominent cholinergic innervation, which is thought to play an important role in the regulation of its normal function. Electrophysiological studies have shown that activation of muscarinic cholinergic receptors results in a marked enhancement of excitatory stimuli onto cortical neurons. In the present study, we examined the effects of acetylcholine (ACh) and its muscarinic agonists (applied by pressure injection) on the response components of individual cortical neurons in layers IV and V of the rat somatosensory cortex in identified barrels (C2 and C3). It was found that the muscarinic agonists could modify the evoked unit activity (in most cases, they caused units to respond to previously minimally effective whisker stimuli), but the modulatory effect was highly dependent on the stimulus parameters, and in most cases, the effect was limited to only one component of 'on' or 'off' responses consisting of 2-4 spikes.

Item Type: Article
Subjects: R Medicine / orvostudomány > RZ Other systems of medicine / orvostudomány egyéb területei
Depositing User: Erika Bilicsi
Date Deposited: 13 Nov 2012 15:56
Last Modified: 13 Nov 2012 15:56
URI: http://real.mtak.hu/id/eprint/3363

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