The importance of drug transporters in human pluripotent stem cells and in early tissue differentiation

Apáti, Ágota and Szebényi, Kornélia and Erdei, Zsuzsa and Várady, György and Orbán, Tamás I. and Sarkadi, Balázs (2016) The importance of drug transporters in human pluripotent stem cells and in early tissue differentiation. Expert Opinion on Drug Metabolism & Toxicology, 12 (1). pp. 77-92. ISSN 1742-5255 (Print), 1744-7607 (Online)


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Introduction: Drug transporters are large transmembrane proteins which catalyse the movement of a wide variety of chemicals, including drugs as well as xeno- and endobiotics through cellular membranes. The major groups of these proteins include the ATP-binding cassette transporters which in eukaryotes work as ATP-fuelled drug exporters and the Solute Carrier transporters, with various transport directions and mechanisms.Areas covered: In this review, we discuss the key ATP-binding cassette and Solute Carrier drug transporters which have been reported to contribute to the function and/or protection of undifferentiated human stem cells and during tissue differentiation. We review the various techniques for studying transporter expression and function in stem cells, and the role of drug transporters in foetal and placental tissues is also discussed. We especially focus on the regulation of transporter expression by factors modulating cell differentiation properties and on the function of the transporters in adjustment to environmental challenges.Expert opinion: The relatively new and as yet unexplored territory of transporters in stem cell biology may rapidly expand and bring important new information regarding the metabolic and epigenetic regulation of stemness and the early differentiation properties. Drug transporters are clearly important protective and regulatory components in stem cells and differentiation. © 2015 Taylor & Francis.

Item Type: Article
Uncontrolled Keywords: Stem Cells; SLC transporters; regulation of transporter expression; pluripotent; human stem cell differentiation; DRUG TRANSPORTERS; ABC TRANSPORTERS
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
Depositing User: MTMT SWORD
Date Deposited: 13 Apr 2016 11:03
Last Modified: 13 Apr 2016 11:03

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