A three-component reagent system for rapid and mild removal of O-, N- and S-trityl protecting groups

Kicsák, Máté and Bege, Miklós and Bereczki, Ilona and Csávás, Magdolna and Herczeg, Mihály and Kupihár, Zoltán and Kovács, Lajos and Borbás, Anikó and Herczegh, Pál (2016) A three-component reagent system for rapid and mild removal of O-, N- and S-trityl protecting groups. ORGANIC & BIOMOLECULAR CHEMISTRY, 14 (12). pp. 3190-3192. ISSN 1477-0520

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Abstract

A new reagent system consisting of a Lewis acid such as BF3·Et2O or Cu(OTf)2, the mild protic acid hexafluoroisopropanol and the reducing quenching agent triethylsilane was elaborated for O-, N- and S-detritylation of nucleoside, carbohydrate and amino acid derivatives. The method is compatible with acetyl, silyl, acetal and Fmoc groups.

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