Does Staphylococcus saprophyticus Cause Acute Cystitis only in Young Females, or is there more to the Story? A One-Year Comprehensive Study Done in Budapest, Hungary

Adeghate, Jennifer and Juhász, Emese and Pongrácz, Júlia and Rimanóczy, Éva and Kristóf, Katalin (2016) Does Staphylococcus saprophyticus Cause Acute Cystitis only in Young Females, or is there more to the Story? A One-Year Comprehensive Study Done in Budapest, Hungary. Acta Microbiologica et Immunologica Hungarica, 63 (1). pp. 57-67. ISSN 1217-8950

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Abstract

Staphylococcus saprophyticus is a well-known urinary pathogen in acute cystitis in young females. We completed a retrospective overview of the distribution of urinary tract infections (UTIs) occurring in 2014, at Semmelweis University hospitals and at Heim Pál Children’s Hospital. Six age-groups (ages 0–100) were examined, with the frequency of S. saprophyticus in females being: 0.1% (0–4), 0.7%, (5–15), 7.4% (16–24), 1.2% (25–39), 0.4% (40–59) and 0.1% (60–100), and S. saprophyticus being the 3^rd most common pathogen in females aged 16–24. In males, S. saprophyticus was only isolated from those aged 5–15. Seasonal distribution of UTIs caused by S. saprophyticus showed that most infections occurred during the months of January, June, August and November. Antibiotic-resistance rates of amoxicillin, clindamycin, doxycycline, erythromycin, gentamicin and sulfamethoxazole- trimethoprim varied as follows: 0.9%, 32.7%, 19.6%, 34.6%, 0.9% and 0.9%, respectively. Thirty randomly selected samples were analysed by pulsed-field gelelectrophoresis, and 28 different genotypes were identified. S. saprophyticus is involved in the pathogenesis of acute cystitis not only in young females, but also in other age-groups, and in young males as well. We did not find any significant seasonal occurrence in S. saprophyticus-caused UTIs. The infective strains were genetically diverse. Antibiotic-resistance does not pose any issue as of yet.

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