Protective effects of Vitamin E on CCl<sub>4</sub>-induced testicular toxicity in male rats

El-Faras, AA and Sadek, IA and Ali, YE and Khalil, MIM and Mussa, EB (2016) Protective effects of Vitamin E on CCl<sub>4</sub>-induced testicular toxicity in male rats. Physiology International (Acta Physiologica Hungarica), 103 (2). pp. 157-168. ISSN 2498-602X


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The increased generation of free radicals plays an important role in testicular damage. The present study aimed to investigate the adverse effects of carbon tetrachloride (CCl<sub>4</sub>) on the reproductive system of male rats as well as to examine whether Vitamin E (VE) is able to ameliorate these effects. The rats were equally divided into three groups: control, CCl<sub>4</sub>-treated, and CCl<sub>4</sub> + VE-treated groups. After 4 weeks of treatment, the decrease in body and testes weights, sperm parameters, and the decrease in serum levels of testosterone, luteinizing hormone, and follicle-stimulating hormone of CCl<sub>4</sub>-treated rats were ameliorated by VE treatment. The co-administration of VE with CCl<sub>4</sub> significantly decreased the level of lipid peroxidation production (malondialdehyde) and increased the activity of anti-oxidant enzymes (superoxide dismutase and catalase) when compared with the CCl<sub>4</sub> group. Moreover, VE prevented CCl<sub>4</sub>-induced severe testicular histopathological lesions and deformities in spermatogenesis. The results demonstrate that VE augments the anti-oxidants’ defense mechanism against CCl<sub>4</sub>-induced reproductive toxicity suggesting a therapeutic role in free radical-mediated infertility.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: Ágnes Sallai
Date Deposited: 27 Jul 2016 09:20
Last Modified: 30 Jun 2017 23:24

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