The preventive effect of β adrenoceptor stimulation against experimentally induced reflux esophagitis

Malek, H.A. and Shalaby, A. (2015) The preventive effect of β adrenoceptor stimulation against experimentally induced reflux esophagitis. Acta Physiologica Hungarica , 102 (1). pp. 94-104. ISSN 0231-424X

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Abstract

A β adrenoceptor agonist plays an important regulatory role in stimulation of thermogenesis and lipolysis and it appears to have anti-ulcer and spasmolytic effects. So the present aim was to examine the effect of BRL 37344 (a selective B₃ adrenoceptor agonist) on reflux esophagitis. Methods Forty-eight rats were divided into twelve sham-operated rats and thirty-six rats with induced reflux esophagitis (RE), which were divided into either RE alone or pretreated with BRL 37344 and/or omeprazole with or without indomethacin. RE was induced in rats, then gastric acid output, pH, plasma nitric oxide (NO), esophageal PGE₂, malondialdehyde (MDA) and reduced glutathione (GSH) were measured and the esophageal injury was assessed by macroscopic damage score. Results Pretreatment with BRL significantly increased plasma NO, GSH, decreased acid output, esophageal MDA and esophageal injury in comparison to pretreatment. In addition, there was a no significant increase in esophageal PGE₂. Conclusion It can be concluded that BRL 37344 has an anti-oxidant protective effect in rats with RE.

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