Prevalence of regulatory T cell subtypes in preeclampsia

Toldi, Gergely and Vásárhelyi, Zsófia Eszter and Rigó, János, Jr. and Orbán, Csaba and Tamássy, Zita and Bajnok, Anna and Shima, Tomoko and Saito, Shigeru and Molvarec, Attila (2015) Prevalence of regulatory T cell subtypes in preeclampsia. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 74 (2). pp. 110-115. ISSN 1046-7408

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Problem: The prevalence of regulatory T cells (Tregs) is lower in preeclampsia (PE) compared to healthy pregnancy (HP). However, the proportion of recently described Treg subtypes has not been investigated. Method: Peripheral blood samples of 19 PE and 21 HP women in the third trimester were evaluated using flow cytometry for the prevalence of activated T cells and naive, effector, thymic, extrathymic, and exhausted Tregs. Results: The prevalence of activated T cells and exhausted Tregs was higher in PE than in HP. The prevalence of the functionally most active effector Tregs is decreased, while naive Tregs appear to be unaffected in PE compared to HP. No difference was detected between Tregs according to their origin (thymic or extrathymic). Conclusion: The combination of lower effector Treg and higher exhausted Treg prevalence may account for the decrease in the functionality of Tregs in PE.

Item Type: Article
Subjects: R Medicine / orvostudomány > RG Gynecology and obstetrics / nőgyógyászat, szülészet
Depositing User: Dr. Attila Molvarec
Date Deposited: 26 Sep 2016 09:10
Last Modified: 26 Sep 2016 09:13

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