Transcriptional outcomes (fates) in response to DNA damage

Újfaludi, Zsuzsanna and Borsos, Barbara and Bonhomme, Celine and Chen, David and Soutoglou, Evi and Pankotai, Tibor (2016) Transcriptional outcomes (fates) in response to DNA damage. In: Annual Meeting of the Hungarian Biochemical Society, 2016, Szeged.

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Abstract

Various types of DNA damage interfere with key vital processes which use DNA as a template, like replication and transcription. Upon large amount of genotoxic impacts, transcription is over-activated and probably results in the activation of several DNA damage recognition processes. During transcrip-tion, numerous components of the transcription machinery may act as a platform to recruit repair proteins at break sites. In contrast to that, when DNA damage occurs at a transcribing unit, it leads to transcriptional block. This multistep process in-volves several kinases and the ubiquitin ligases like NEDD4 and CUL3 leading to proteasome dependent degradation of RNA polymerase II (RNAPII) which happens at the site of the damage. Finally, at the break site ddRNA (a new class of noncoding RNA) production could be observed by controlling the DDR activation at sites of DNA damage. Taken together these results support an uncharacterized function of RNAPII complexes which allow the rec-ognition of DNA damages and like this enhance cell survival following DNA damage. This work was supported by OTKA-PD [112118], and the János Bolyai Research Scholarship of the Hungarian Acad-emy of Sciences.

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