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Impact of CT-apelin and NT-proBNP on identifying non-responders to cardiac resynchronization therapy.

Kosztin, Annamária and Széplaki, Gábor and Kovács, Attila and Földes, Gábor and Szokodi, István and Nagy, Vivien Klaudia and Kutyifa, Valentina and Fórizs, Éva and Végh, M. Eszter and Gellér, László and Becker, Dávid and Aradi, Dániel and Merkely, Béla (2016) Impact of CT-apelin and NT-proBNP on identifying non-responders to cardiac resynchronization therapy. Biomarkers, 21. pp. 1-8. ISSN 1354-750X (Print) 1366-5804 (Online)

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Abstract

CONTEXT: Assessment of response to cardiac resynchronization therapy (CRT) is essential. OBJECTIVE: To assess the predictive value of CT-apelin together with NT-proBNP in patients undergoing CRT. METHODS: Serum CT-apelin and NT-proBNP were measured by ELISA before, and six months after CRT. Primary endpoint was non-response (<4% increase in LVEF) after six months. RESULTS: From 81 patients, 15 proved to be non-responders. Six-month CT-apelin was superior compared to NT-proBNP in identifying non-responders by multivariate ROC (CT-apelin: p = 0.01, NT-proBNP: p = 0.13) and by logistic regression (CT-apelin: p = 0.01, NT-proBNP: p = 0.41) analyses. CONCLUSION: Six-month CT-apelin might be a valuable novel biomarker in identifying non-responders to CRT that was superior to NT-proBNP.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában > R850-854 Experimental medicine / kisérleti orvostudomány
R Medicine / orvostudomány > RC Internal medicine / belgyógyászat
Depositing User: Dr Dániel Aradi
Date Deposited: 10 Oct 2016 07:08
Last Modified: 10 Oct 2016 07:08
URI: http://real.mtak.hu/id/eprint/41710

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