Kinetic studies on the manganese(II) complex catalyzed oxidation of epinephrine

Szigyártó, Imola Csilla and Szabó, László and Simándi, László (2013) Kinetic studies on the manganese(II) complex catalyzed oxidation of epinephrine. Journal of Molecular Catalysis A: Chemical, 372. pp. 66-71. ISSN 1381-1169

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The manganese complex [Mn2(HL)2](BPh4)2 was found to be a selective catalyst for the oxidation of epinephrine (a catecholamine derivative) to adrenochrome at room temperature in sodium carbonate-bicarbonate buffer. The epinephrine auto-oxidation rate significantly increases upon the addition of manganese complex. The kinetics of reaction was studied by spectrophotometric method, monitoring the increase in concentration of adrenochrome product. According to the proposed mechanism, O2 binding to the manganese complex is followed by the formation of a ternary catalyst-dioxygen-substrate complex as active intermediate, which decomposes in a rate-determining step, generating the adrenochrome.

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Q Science / természettudomány > QD Chemistry / kémia
Depositing User: Dr. Imola Csilla Szigyártó
Date Deposited: 03 May 2013 12:50
Last Modified: 03 May 2013 12:50

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