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Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide-treated mice

Er, Ayse and Yazar, Enver and Uney, Kamil and Elmas, Muammer and Altan, Feray and Cetin, Gul (2010) Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide-treated mice. Acta Veterinaria Hungarica, 58 (1). pp. 75-81. ISSN 0236-6290

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Abstract

The effects of different doses of tylosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into seven groups. Lipopolysaccharide (LPS) was injected into the positive control group. The other six groups received three different tylosin doses concurrently without or with LPS: 10 mg/kg, 100 mg/kg, 500 mg/kg, 10 mg/kg + LPS, 100 mg/kg + LPS and 500 mg/kg + LPS. After treatment, serum samples were collected at 0, 1, 2, 3, 6, 12 and 24 hours. Serum tumour necrosis factor α (TNFα), interleukin 1β (IL1β) and IL10 levels were determined by enzyme-linked immunosorbent assay (ELISA). Tylosin doses of 10 and 100 mg/kg induced no cytokine production in the healthy mice. Tylosin at 500 mg/kg had no effect on TNFα or IL1β production, but it induced IL10 production in healthy mice. All doses of tylosin reduced the elevated TNFα and IL1β in LPS-treated mice but increased their IL10 levels. In conclusion, these data suggest that tylosin has an immunomodulatory effect at the dose recommended for use against infection.

Item Type: Article
Subjects: S Agriculture / mezőgazdaság > SV Veterinary science / állatorvostudomány
Depositing User: xKatalin xBarta
Date Deposited: 10 Feb 2017 10:21
Last Modified: 10 Feb 2017 10:21
URI: http://real.mtak.hu/id/eprint/48091

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