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Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis.

Butykai, I. and Orbán, A. and Kocsis, V. and Szaller, D. and Bordács, S. and Tátrai-Szekeres, E. and Kiss, László F. and Bóta, Attila and Vértessy G., Beáta and Zelles, T. and Kézsmárki, I. (2013) Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis. SCIENTIFIC REPORTS, 3. No. 1431. ISSN 2045-2322

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Abstract

Abstract The need to develop new methods for the high-sensitivity diagnosis of malaria has initiated a global activity in medical and interdisciplinary sciences. Most of the diverse variety of emerging techniques are based on research-grade instruments, sophisticated reagent-based assays or rely on expertise. Here, we suggest an alternative optical methodology with an easy-to-use and cost-effective instrumentation based on unique properties of malaria pigment reported previously and determined quantitatively in the present study. Malaria pigment, also called hemozoin, is an insoluble microcrystalline form of heme. These crystallites show remarkable magnetic and optical anisotropy distinctly from any other components of blood. As a consequence, they can simultaneously act as magnetically driven micro-rotors and spinning polarizers in suspensions. These properties can gain importance not only in malaria diagnosis and therapies, where hemozoin is considered as drug target or immune modulator, but also in the magnetic manipulation of cells and tissues on the microscopic scale.

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Depositing User: Dr. Beáta Vértessy
Date Deposited: 30 Apr 2013 12:00
Last Modified: 30 Apr 2013 12:00
URI: http://real.mtak.hu/id/eprint/4954

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