Food-intake regulation during stress by the hypothalamo-pituitary-adrenal axis

Bazhan, Nadezhda and Zelena, Dóra (2013) Food-intake regulation during stress by the hypothalamo-pituitary-adrenal axis. Brain Research Bulletin, 95. pp. 46-53. ISSN 0361-9230

Preview	Text 2013BRB (Nadya food-stress).pdf - Draft Version Download (1MB) | Preview
	Text 2013BRB_Nadya_food-stress.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

The prevalence of obesity is increasing worldwide with serious consequences such as diabetes mellitus type 2 and cardiovascular diseases. Emotional stress is considered to be one of the main reasons of obesity development in humans. However, there are some contradictory results, which should be addressed. First of all stress induces anorexia, but not overeating in laboratory animals. Glucocorticoids, the effector molecules of the hypothalamo-pituitary-adrenocortical (HPA) axis stimulate and stress inhibits food intake. It is also not clear if stress is diabetogenic or an antidiabetogenic factor. The review will discusses these issues and the involvement of the whole HPA axis and its separate molecules (glucocorticoids, adrenocorticotropin, corticotropin-releasing hormone) in food intake regulation under stress.

Actions (login required)

Edit Item