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Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands

Barta Holló, B. and Szilágyi, Imre Miklós and Várhelyi, Csaba, ifj. and Hunyadi, D. and Nagy, R. I. and Szalay, Roland (2017) Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 127 (2). pp. 1733-1741. ISSN 1388-6150

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Abstract

Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)2Cl2] (1), [Pt(pa)2Cl2] (2) and [Pt(aph)2Cl2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESI–MS and NMR), and tested against selected Gram(+) and Gram(–) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(−) bacteria. © 2016 Akadémiai Kiadó, Budapest, Hungary

Item Type: Article
Uncontrolled Keywords: Chlorine compounds; Spectroscopic technique; Pt complexes; Physico-chemical characterization; COORDINATION COMPOUNDS; Anti-microbial activity; Anhydrous compounds; Thermodynamic properties; Synthesis (chemical); platinum; LIGANDS; chelation; BACTERIA; Thermal properties; Spectroscopic data; Pt(II) complexes; ANTIMICROBIAL ACTIVITY; Amine ligand
Subjects: Q Science / természettudomány > QD Chemistry / kémia
Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 31 Mar 2017 09:50
Last Modified: 31 Mar 2017 09:50
URI: http://real.mtak.hu/id/eprint/50798

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