Scaffolds: interaction platforms for cellular signalling circuits

Zeke, András and Lukács, Melinda and Lim, Wendell A. and Reményi, Attila (2009) Scaffolds: interaction platforms for cellular signalling circuits. TRENDS IN CELL BIOLOGY, 19 (8). pp. 364-374. ISSN 0962-8924

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Scaffold proteins influence cellular signalling by binding to multiple signalling enzymes, receptors or ion channels. Although normally devoid of catalytic activity, they have a big impact on controlling the flow of signalling information. By assembling signalling proteins into complexes, they play the part of signal processing hubs. As we learn more about the way signalling components are linked into natural signalling circuits, researchers are becoming interested in building non-natural signalling pathways to test our knowledge and/or to intentionally reprogram cellular behaviour. In this review, we discuss the role of scaffold proteins as efficient tools for assembling intracellular signalling complexes, both natural and artificial.

Item Type: Article
Uncontrolled Keywords: *Signal Transduction; Proteins/*metabolism; Protein Engineering; Humans; Enzymes/metabolism; Cells/*metabolism
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
Depositing User: MTMT SWORD
Date Deposited: 04 Sep 2017 13:35
Last Modified: 04 Sep 2017 13:35

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