Scaffolds are 'active' regulators of signaling modules

Alexa, Anita and Varga, János and Reményi, Attila (2010) Scaffolds are 'active' regulators of signaling modules. FEBS JOURNAL, 277 (21). pp. 4376-4382. ISSN 1742-464X

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Signaling cascades, in addition to proteins with obvious signaling-relevant activities (e.g. protein kinases or receptors), also employ dedicated 'inactive' proteins whose functions appear to be the organization of the former components into higher order complexes through protein-protein interactions. The core function of signaling adaptors, anchors and scaffolds is the recruitment of proteins into one macromolecular complex. Several recent studies have demonstrated that the recruiter and the recruited molecules mutually influence each other in a scaffolded complex. This yields fundamentally novel properties for the signaling complex as a whole. Because these are not merely additive to the properties of the individual components, scaffolded signaling complexes may behave as functionally distinct modules.

Item Type: Article
Uncontrolled Keywords: PATHWAY; DYNAMICS; KSR1; Ste5; PROTEINS; PSD-95; ACTIVATION; PHOSPHORYLATION; POSTSYNAPTIC DENSITY; MAP KINASE CASCADE; signaling scaffold; signaling cascade; PSD95; protein kinase; phosphorylation of scaffold; MAPK module; InaD; cellular signaling
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
Depositing User: MTMT SWORD
Date Deposited: 04 Sep 2017 13:46
Last Modified: 04 Sep 2017 13:46

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