8-Oxo-7,8-dihydroguanine: Links to gene expression, aging, and defense against oxidative stress

Radák, Zsolt and Boldogh, István (2010) 8-Oxo-7,8-dihydroguanine: Links to gene expression, aging, and defense against oxidative stress. FREE RADICAL BIOLOGY AND MEDICINE, 49 (4). pp. 587-596. ISSN 0891-5849

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The one-electron oxidation product of guanine, 8-oxo-7,8-dihydroguanine (8-oxoG), is an abundant lesion in genomic, mitochondrial, and telomeric DNA and RNA. It is considered to be a marker of oxidative stress that preferentially accumulates at the 5' end of guanine strings in the DNA helix, in guanine quadruplexes, and in RNA molecules. 8-OxoG has a lower oxidation potential compared to guanine; thus it is susceptible to oxidation/reduction and, along with its redox products, is traditionally considered to be a major mutagenic DNA base lesion. It does not change the architecture of the DNA double helix and it is specifically recognized and excised by 8-oxoguanine DNA glycosylase (OGG1) during the DNA base excision repair pathway. OGG1 null animals accumulate excess levels of 8-oxoG in their genome, yet they do not have shorter life span nor do they exhibit severe pathological symptoms including tumor formation. In fact they are increasingly resistant to inflammation. Here we address the rarely considered significance of 8-oxoG, such as its optimal levels in DNA and RNA under a given condition, essentiality for normal cellular physiology, evolutionary role, and ability to soften the effects of oxidative stress in DNA, and the harmful consequences of its repair, as well as its importance in transcriptional initiation and chromatin relaxation. © 2010 Elsevier Inc.

Item Type: Article
Uncontrolled Keywords: Animalia; transcription initiation; telomere; protein phosphorylation; priority journal; Pathogenesis; OXIDATIVE STRESS; oxidation reduction potential; nonhuman; molecular evolution; LONGEVITY; Inflammation; human; Gene Expression; Gene Deletion; excision repair; enzyme activity; DNA helix; DNA Damage; ARTICLE; Aging; unclassified drug; reactive oxygen metabolite; mitochondrial RNA; mitochondrial DNA; Guanine; GENOMIC RNA; genomic DNA; DNA glycosyltransferase; 8 oxoguanine dna glycosylase 1; 8 hydroxyguanine; Hormesis; Free Radicals; 8-Oxoguanine DNA glycosylase; 8-Oxo-7,8-dihydroguanine
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: MTMT SWORD
Date Deposited: 06 Sep 2017 13:37
Last Modified: 06 Sep 2017 13:37

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