Production of bioactive compounds by different fungal species

Jekkel, Antónia and Szegedi, M. (1999) Production of bioactive compounds by different fungal species. Acta Microbiologica et Immunologica Hungarica, 46 (2-3). pp. 215-218. ISSN 1217-8950


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Production of cholesterol-lowering drugs Nowadays in Hungary and all over the world there is an increasing demand on cholesterol-lowering drugs. Highest risk factor of atherosclerosis and especially coronary occlusion is the high cholesterol level of the plasma. In the recent two decades the 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC. as the rate limiting key enzyme of the cholesterol biosynthesis in the organism was extensively examined. Mevinolin and other related compounds (compactin, pravastatin, simvastatin) are the competitive inhibitors of the HMG-CoA reductase enzyme. Our investigations were focussed on finding microorganisms, which would produce HMG-CoA reductase enzyme inhibitors. During screening, covering about 20,000 fungus strains two microorganisms were selected, one of them an Aspergillusspecies was able to biosynthesize mevinolin and another strain belongs to thePenicilliumgenus was able to produce compactin. In the course of our experiments new, economic microbial processes were developed for both cholesterol-lowering agents.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
Depositing User: xFruzsina xPataki
Date Deposited: 10 Sep 2017 10:36
Last Modified: 31 May 2019 23:15

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